Master of Science (MS)
Kinesiology and Nutrition Sciences
First Committee Member
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Background: Global DNA Methylation (GDM), an epigenomic modification has been linked to the development of Cardiovascular Disease and its risk factors. Purpose: The purpose of this study was to determine if there is a significant correlation between GDM and cardiovascular fitness, as well as, measures of body composition. Methodology: 26 apparently healthy, adults (11 males) completed a physical activity and diet questionnaire, as well as, had a small blood sample (600μL) collected via finger prick for the determination of GDM. Body composition was assessed by means of a Dual-Energy X-ray Absorptiometry (DEXA) scan, while cardiovascular fitness was evaluated by the completion of a maximal exertion, graded exercise test (VO2max) on a treadmill. Peasron's "r" value was used to determine the correlation GDM and various variables, while t-tests were used to determine if any differences between high and low value groups for each variable existed. Results: Body Mass Index was significantly correlated (p-value, r value; 0.031, -.556) with GDM while there was a significant difference between high and low level folate groups (p=0.034) as determined by the diet questionnaire. No significant correlations or differences were found in males. Conclusion: The results conclude that as BMI increases, GDM decreases in females. In attempts to further investigate the relationships between GDM and these variables, auxiliary research needs to be conducted with larger subject pools containing additional sedentary participants.
Cardiovascular fitness; Cardiovascular system – Diseases – Prevention; Cardiovascular system – Diseases – Risk factors; DEXA; DNA – Methylation; Dual-energy X-ray absorptiometry; Exercise; Methylation; Physical activity; Vo2max
Cardiovascular Diseases | Exercise Science | Genetics | Kinesiology | Medicine and Health Sciences
Jarrett, Michael Steele, "Relationship of Global DNA Methylation with Cardiovascular Fitness and Body Composition" (2013). UNLV Theses, Dissertations, Professional Papers, and Capstones. 1932.