Master of Science (MS)
Health Physics and Diagnostic Sciences
First Committee Member
Second Committee Member
Third Committee Member
Fourth Committee Member
Fifth Committee Member
Sixth Committee Member
Kathryn H. Korgan
Number of Pages
Although both chemotherapy and hyperthermia therapy have their inherent advantages, the non-specific targeting of chemotherapy and ineffectiveness of hyperthermia therapy alone suggests a better method can be developed. To overcome this problem, the combined treatment of chemotherapeutic agents with plasmonic photothermal therapy (PPTT) is proposed. This is the first study to investigate the efficacy of combined chemotherapy and PPTT using monocytes as delivery vehicles for gold nanoshells. The results of this investigation shows that PPTT combined with cisplatin resulted in some degree of synergism while additive effects were observed for concurrent treatments of PPTT and doxorubicin and PPTT and bleomycin.
Chemotherapeutic Agents; Macrophage; Plasmonic Photothermal Therapy
Medical Sciences | Medicine and Health Sciences
Shih, En Chung, "In Vitro Efficacy of Combined Macrophage-Mediated Plasmonic Photothermal Therapy and Chemotherapeutic Agents" (2015). UNLV Theses, Dissertations, Professional Papers, and Capstones. 2427.