Master of Science (MS)
Kinesiology and Nutrition Sciences
First Committee Member
James W. Navalta
Second Committee Member
Third Committee Member
Fourth Committee Member
Number of Pages
Introduction: Emerging research suggests that the lymphocyte immune response during exercise is amplified in individuals who are positive for human cytomegalovirus (HCMV+). However, the responses of monocytes and neutrophils in HCMV+ individuals are unknown. HCMV, a type of herpes virus, infects 50% or more of the adult population in the United States. This virus can become a cause for concern in individuals who have a compromised immune system, which has been shown to occur after high-intensity exercise.
Purpose: The purpose of this study was to characterize the lymphocyte, monocyte, and neutrophil responses to exercise in HCMV+ individuals.
Methods: Participants were male (n = 7) and female (n = 9), between the ages of 18 and 44 (26.38 + 8.94) years old. Participants were either positive (HCMV+) or negative (HCMV-) for HCMV. Participants visited the Exercise Physiology laboratory on three separate occasions: (1) HCMV screening, (2) 100% VO2max test, (3) 80% VO2max run for 20 minutes. Four blood samples were taken during the third visit: (1) Pre-exercise, (2) Post-exercise, (3) 30 minutes post-exercise, and (4) 60 minutes post-exercise. 2 (virus status) x 4 (sampling condition) mixed-model factorial ANOVA procedures with repeated measures on sampling condition were performed on absolute and relative circulating lymphocytes, monocytes, and neutrophils.
Results: No interactions of absolute or relative values for HCMV status and time were found for any of the three leukocyte subsets. Significant main effects for time for both absolute (neutrophils: p < .001; monocytes: p < .001; lymphocytes: p < .001) and relative (neutrophils: p < .001; monocytes: p < .001; lymphocytes: p < .001) values were seen for all leukocyte subsets regardless of virus status. Significant differences for absolute and relative values were seen between sampling conditions for all leukocyte subsets.
Discussion: The effects of high-intensity exercise on circulating monocyte and neutrophil volumes in the post-exercise period were the main findings of this study. We report for the first time that HCMV status does not affect circulating neutrophil responses to high-intensity exercise, though exercise-induced neutrocytosis (a significant increase in neutrophil volume) is seen during the post-exercise and 60 minutes post-exercise sampling conditions, regardless of HCMV status. There is no HCMV effect on circulating monocyte responses to exercise, though exercise-induced monocytosis was seen during the post-exercise sampling condition regardless of HCMV status.
Cytomegalovirus; Exercise; Leukocyte; Lymphocyte; Monocyte; Neutrophil
Immunity | Immunology and Infectious Disease | Medicine and Health Sciences
University of Nevada, Las Vegas
Wilson, Jared Nicholas, "Leukocyte Responsiveness to Exercise in HCMV+ Individuals" (2015). UNLV Theses, Dissertations, Professional Papers, and Capstones. 2448.
IN COPYRIGHT. For more information about this rights statement, please visit http://rightsstatements.org/vocab/InC/1.0/