Master of Science (MS)
Health Physics and Diagnostic Sciences
First Committee Member
Second Committee Member
Third Committee Member
Fourth Committee Member
Number of Pages
Radiation-induced esophageal cancer can be a deadly and unfortunate secondary outcome of radiotherapy or chronic occupational exposure to radiation. Although the esophagus is known to be a radiosensitive organ, it is under studied and further information regarding how dose and radiation quality impact its sensitivity may provide strategies to prevent esophageal cancer. The purpose of this thesis was to understand factors that play a role in the tissue’s radiosensitivity that may relate to its cancer risk. In this study, we used two esophageal 3D models, as well as both human and mouse cells, to define radiation quality and dose dependent changes. The study details radiation-quality and dose dependent changes in: tissue morphology, MAPK/SAPK phospho-protein expression, crosstalk between the TGFβ and ATM pathways, and DNA damage kinetics. The results are complex, but provide not only radiation quality and dose dependent differences, but also species and cell type specific differences in response to radiation. The latter are especially critical to note when extrapolating results using different model systems. In total, the results suggest that esophageal tissue is sensitive to high vs. low linear energy transfer (LET) radiation. In addition, radiation induced changes in phospho-expression may underlie the changes in tissue morphology and result from alterations in proliferation and/or differentiation. Lastly, although a definitive answer underlying the rationale for the greater sensitivity of the esophagus to radiation was not defined, these studies have provided relevant key findings to pursue in future studies that should help to resolve this question.
Cancer; Esophageal tissue; Radiation
Medicine and Health Sciences
University of Nevada, Las Vegas
Pryor, Latisha T., "Factors Affecting Esophageal Tissue Radiation Response" (2020). UNLV Theses, Dissertations, Professional Papers, and Capstones. 4020.
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