Award Date


Degree Type


Degree Name

Master of Science (MS)


Health Physics and Diagnostic Sciences

First Committee Member

Steen Madsen

Second Committee Member

Travis H. Snyer

Third Committee Member

Francis Cucinotta

Fourth Committee Member

Janice Pluth

Fifth Committee Member

Graham McGinnis

Number of Pages



Traumatic Brain Injury (TBI) is a global health challenge, with over 4.6 million

confirmed cases annually in North America alone. Mild traumatic brain injuries

(mTBIs) are the most common and make up approximately 81% of all TBI diagnoses

worldwide [1]. Studies indicate that 10–15% of patients suffer from trauma induced

symptoms (i.e. headache, loss of balance, cognitive impairments, fatigue, and mental

health/affective disorders) as far as 1 year post injury [2]. Prediction and management

of these post-traumatic sequalae is complicated by a lack of symptom associated

neuroimaging findings. In spite of a “prominent distribution” of frontotemporal WMHs

in pediatric subjects with mTBI, a 2016 study (N=72) by Bigler et al. found no

association between unique changes in cortical thickness and WMHs after statistical

correction for multiple comparisons. This retrospective study will investigate the

associations between cortical thinning, white matter hyperintensities, and clinical

outcomes in a large (N=147) and neurodevelopmentally diverse (18-40 years-old) group

of subjects diagnosed with mTBI. Regional (Frontal Lobe, Temporal Lobe, Occipital

Lobe, Parietal Lobe, and Cerebellum) volumetric and WMH data was obtained for all

147 patients. Assessment of image finding correlation showed that white matter

hyperintensities did not consistently coincide with cortical thinning as defined by the

NeuroQuant normative percentile values. Interval-censored analysis revealed

statistically significant associations between positive WM status and longevity of post-

concussive cognitive deficits (p<0.024)


Clinical Outcomes; Concussion; Cortical thinning; DAI; mTBI; White matter hyperintensities


Medical Neurobiology | Neuroscience and Neurobiology | Neurosciences

File Format


File Size

976 KB

Degree Grantor

University of Nevada, Las Vegas




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