Title
Enrichment Factors for Clinical Trials in Mild-to-Moderate Alzheimer’s Disease
Document Type
Article
Publication Date
1-1-2019
Publication Title
Alzheimer’s and Dementia
Volume
5
First page number:
164
Last page number:
174
Abstract
Heterogeneity of outcomes in Alzheimer’s disease (AD) clinical trials necessitates large sample sizes and contributes to study failures. This analysis determined whether mild-to-moderate AD populations could be enriched for cognitive decline based on apolipoprotein (APOE)ε4 genotype, family history of AD, and amyloid abnormalities.
Keywords
Alzheimer’s disease; Clinical trial; Enrichment; Power; Biomarkers
Disciplines
Medicine and Health Sciences
Language
English
Repository Citation
Ballard, C.,
Atri, A.,
Boneva, N.,
Cummings, J. L.,
Frolich, L.,
Molinuevo, J.,
Tariot, P. N.,
Raket, L.
(2019).
Enrichment Factors for Clinical Trials in Mild-to-Moderate Alzheimer’s Disease.
Alzheimer’s and Dementia, 5
164-174.
http://dx.doi.org/10.1016/j.trci.2019.04.001
COinS