Ent-Labdane Diterpenoids from the Aerial Parts of Eupatorium Obtusissmum

Authors

Quírico A. Castillo, Ciudad Universitaria
Jorge Triana, Universidad de Las Palmas de Gran Canaria
José L. Eiroa, Universidad de Las Palmas de Gran Canaria
Laurent Calcul, University of South Florida
Edwin Rivera, University of South Florida
Lukasz Wojtas, University of South Florida
José M. Padrón, Universidad de la Laguna
Lise Boberieth, University of South Florida
Mehdi Keramane, Institute, McMaster University
Ernesto Abel-Santos, University of Nevada, Las VegasFollow
Luis A. Báez, Ciudad Universitaria
Evelyn A. Germosén, Ciudad Universitaria

Document Type

Article

Publication Date

1-1-2016

Publication Title

Journal of Natural Products

Volume

79

Issue

4

First page number:

907

Last page number:

913

Abstract

Six new ent-labdane diterpenoids, uasdlabdanes A-F (1-6), were isolated from the aerial parts of Eupatorium obtusissmum. The new structures were elucidated through spectroscopic and spectrometric data analyses. The absolute configurations of compounds 1 and 2 were established by X-ray crystallography, and those of 3-6, by comparison of experimental and calculated electronic circular dichroism spectra. The antiproliferative activity of the compounds was studied in a panel of six representative human solid tumor cell lines and showed GI50 values ranging from 19 to >100 μM. © 2016 The American Chemical Society and American Society of Pharmacognosy.

File Format

pdf

File Size

968.82 KB

Language

English

Repository Citation

Castillo, Q. A., Triana, J., Eiroa, J. L., Calcul, L., Rivera, E., Wojtas, L., Padrón, J. M., Boberieth, L., Keramane, M., Abel-Santos, E., Báez, L. A., Germosén, E. A. (2016). Ent-Labdane Diterpenoids from the Aerial Parts of Eupatorium Obtusissmum. Journal of Natural Products, 79(4), 907-913.
http://dx.doi.org/10.1021/acs.jnatprod.5b00954