Title

Ent-Labdane Diterpenoids from the Aerial Parts of Eupatorium Obtusissmum

Document Type

Article

Publication Date

1-1-2016

Publication Title

Journal of Natural Products

Volume

79

Issue

4

First page number:

907

Last page number:

913

Abstract

Six new ent-labdane diterpenoids, uasdlabdanes A-F (1-6), were isolated from the aerial parts of Eupatorium obtusissmum. The new structures were elucidated through spectroscopic and spectrometric data analyses. The absolute configurations of compounds 1 and 2 were established by X-ray crystallography, and those of 3-6, by comparison of experimental and calculated electronic circular dichroism spectra. The antiproliferative activity of the compounds was studied in a panel of six representative human solid tumor cell lines and showed GI50 values ranging from 19 to >100 μM. © 2016 The American Chemical Society and American Society of Pharmacognosy.

Language

English

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