Catalyst-free Synthesis of α1-oxindole-α-Hydroxyphosphonates Via Phospha-aldol Reaction of Isatins Employing N-heterocyclic Phosphine (NHP)-thiourea

Authors

Nagaraju Molleti, University of Nevada, Las Vegas
Jun Yong Kang, University of Nevada, Las VegasFollow

Document Type

Article

Publication Date

9-9-2016

Publication Title

Organic & Biomoleculer Chemistry

Volume

14

Issue

38

First page number:

8952

Last page number:

8956

Abstract

A highly efficient phospha-aldol reaction for the synthesis of α1-oxindole-α-hydroxyphosphonates is developed utilizing N-heterocyclic phosphine (NHP)-thiourea as a phosphonylation reagent under catalyst, additive free conditions. This methodology encompasses a variety of isatin derivatives to provide α1-oxindole- α-hydroxyphosphonates up to 99% yield.

Repository Citation

Molleti, N., Kang, J. Y. (2016). Catalyst-free Synthesis of α1-oxindole-α-Hydroxyphosphonates Via Phospha-aldol Reaction of Isatins Employing N-heterocyclic Phosphine (NHP)-thiourea. Organic & Biomoleculer Chemistry, 14(38), 8952-8956.
http://dx.doi.org/10.1039/C6OB01608A