Synthesis of Diaryl Diazaphosphonates via 1,6-Hydrophosphonylation of p-Quinone Methides with N-Heterocyclic Phosphine-Thioureas

Authors

Nagaraju Molleti, University of Nevada, Las Vegas
Jun Yong Kang, University of Nevada, Las VegasFollow

Document Type

Article

Publication Date

1-1-2017

Publication Title

Organic Letters

Volume

19

Issue

4

First page number:

958

Last page number:

961

Abstract

A mild, efficient method for the synthesis of diaryl diazaphosphonates via 1,6-hydrophosphonylation/aromatization of p-quinone methides (p-QMs) with N-heterocyclic phosphine-thioureas has been developed. This transformation proceeds without any additive or catalyst under mild reaction conditions and tolerates a wide range of p-QMs. This methodology provides a straightforward access to diaryl phosphonate derivatives in good to excellent yields (up to 99%). © 2017 American Chemical Society.

Language

english

Repository Citation

Molleti, N., Kang, J. Y. (2017). Synthesis of Diaryl Diazaphosphonates via 1,6-Hydrophosphonylation of p-Quinone Methides with N-Heterocyclic Phosphine-Thioureas. Organic Letters, 19(4), 958-961.
http://dx.doi.org/10.1021/acs.orglett.7b00261