Self-regulating Ubiquitin Ligases
Document Type
Article
Publication Date
1-1-2017
Publication Title
EMBO Journal
Abstract
Occasional auto-modification of ubiquitin ligases typically leads to their proteasomal destruction, but new findings published in The EMBO Journal now show that in the case of Rsp5/Nedd4, auto-ubiquitylation instead triggers oligomerization and concomitant reduction of ligase activity. This novel mechanism therefore creates silenced ligases that remain poised for reactivation. © 2017 EMBO.
Language
english
Repository Citation
Hill, S.,
Kleiger, G.
(2017).
Self-regulating Ubiquitin Ligases.
EMBO Journal
http://dx.doi.org/10.15252/embj.201696154
