Acid Sphingomyelinase Regulates the Localization and Trafficking of Palmitoylated Proteins

Authors

Xiahui Xiong, University of Nevada, Las VegasFollow
Chia-Fang Lee, Protea Biosciences
Wenjing Li, University of Nevada, Las VegasFollow
Jiekai Yu, University of Nevada, Las VegasFollow
Linyu Zhu, University of Nevada, Las Vegas
Yongsoon Kim, University of Nevada, Las Vegas
Hul Zhang, University of Nevada, Las VegasFollow
Hong Sun, University of Nevada, Las VegasFollow

Document Type

Article

Publication Date

5-29-2019

Publication Title

Biology Open

Publisher

Company of Biologists

First page number:

1

Last page number:

56

Abstract

In human, loss of Acid Sphingomeylinase (ASM/SMPD1) causes Niemann-Pick Disease, type A. ASM hydrolyzes sphingomyelins to produce ceramides but protein targets of ASM remain largely unclear. ... See full text for complete abstract.

Keywords

Acid sphingomyelinase; Ceramide; Lipid raft; Proteomics; Protein palmitoylation; Protien trafficking; Plasa membrane; Golgi

Disciplines

Biochemistry, Biophysics, and Structural Biology

File Format

pdf

File Size

1.888 KB

Language

English

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 License.

Repository Citation

Xiong, X., Lee, C., Li, W., Yu, J., Zhu, L., Kim, Y., Zhang, H., Sun, H. (2019). Acid Sphingomyelinase Regulates the Localization and Trafficking of Palmitoylated Proteins. Biology Open 1-56. Company of Biologists.
http://dx.doi.org/10.1242/bio.040311