Selective Hydrolysis of Phosphorus(V) Compounds to Form Organophosphorus Monoacids
Document Type
Article
Publication Date
6-14-2021
Publication Title
Organic and Biomolecular Chemistry
Issue
27
First page number:
1
Last page number:
8
Abstract
An azide and transition metal-free method for the synthesis of elusive phosphonic, phosphinic, and phosphoric monoacids has been developed. Inert pentavalent P(V)-compounds (phosphonate, phosphinate, and phosphate) are activated by triflate anhydride (Tf2O)/pyridine system to form a highly reactive phosphoryl pyridinium intermediate that undergoes nucleophilic substitution with H2O to selectively deprotect one alkoxy group and form organophosphorus monoacids.
Disciplines
Chemistry
Language
English
Repository Citation
Ash, J.,
Huang, H.,
Cordero, P.,
Kang, J. Y.
(2021).
Selective Hydrolysis of Phosphorus(V) Compounds to Form Organophosphorus Monoacids.
Organic and Biomolecular Chemistry(27),
1-8.
http://dx.doi.org/10.1039/D1OB00881A