Document Type
Conference Proceeding
Publication Date
1-1-2021
Publication Title
IOP Conference Series: Earth and Environmental Science
Publisher
IOP Publishing
Volume
779
Issue
1
First page number:
1
Last page number:
9
Abstract
New mono- and bis-dithiocarbamates were prepared from the reaction of organic dihydrazides -NHNH-(C=O)(CH2)x-(C=O)NHNH- (where x = 0, 2, 4) and basic carbon disulfide with varying chain length 10-14 atom as a human serum metal carrier. The products were characterized by various spectrophotometric such as 1H and 13C NMR and elemental analysis. Their antiproliferative activities were examined on two species of the standard strains of the Gram-positive Staphylococcus aureus ATCC 25923 and Gram-negative Escherichia coli ATCC 25922 by following the procedure of broth micro-dilution method (BMM), which was applied at the concentrations: 0.0, 100, 200, and 300 ppm for each compound. The antioxidant properties were investigated by following the DPPH method, which was applied for each of the above concentrations. All prepared compounds exhibited antiproliferative and antioxidant activity.
Keywords
Antioxidant; Antiproliferative activity; Dithiocarbamates; DPPH; Drug delivery; Metal carrier
Disciplines
Chemicals and Drugs | Medicine and Health Sciences
File Format
File Size
783 KB
Language
English
Rights
IN COPYRIGHT. For more information about this rights statement, please visit http://rightsstatements.org/vocab/InC/1.0/
Creative Commons License
This work is licensed under a Creative Commons Attribution 3.0 License.
Repository Citation
Al-Nuzal, S. M.,
Haleem, A. M.,
Czerwinski, K.,
Haleem, S. M.
(2021).
New Dithiocarbamates as a Possible Human Serum Albumin Metal Carrier in Drug Delivery Systems and Their Antioxidant and Antiproliferative Activities.
IOP Conference Series: Earth and Environmental Science, 779(1),
1-9.
IOP Publishing.
http://dx.doi.org/10.1088/1755-1315/779/1/012048