Document Type
Article
Publication Date
3-1-2024
Publication Title
Molecules
Volume
29
Issue
5
First page number:
1
Last page number:
12
Abstract
The current study describes a novel and eco-conscious method to synthesize 1,4-dihydropyridine derivatives utilizing an aqueous micellar solution containing aluminum dodecyl sulfate, Al(DS)3, using readily available starting material. The final products were synthesized with excellent yields within remarkably quick reaction durations, promoting remarkable atom economy and minimizing environmental impacts. The present protocol has several advantages over other methodologies in terms of high yield (up to 97%) with excellent purity. Further, the synthesized 1,4-DHPs exhibit favorable to excellent resistance against examined bacterial and fungal species. Intriguingly, polar groups on the phenyl ring (5b, 5c, 5i and 5j) make the 1,4-DHPs equally potent against the microbes as compared to the standard drugs.
Keywords
multi-component reaction; 1,4-dihydropyridines; microwave; heterocyclic compounds; Al(DS)3; green synthesis
Disciplines
Biochemistry | Medicinal Chemistry and Pharmaceutics
File Format
File Size
1991 KB
Language
English
Rights
IN COPYRIGHT. For more information about this rights statement, please visit http://rightsstatements.org/vocab/InC/1.0/
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Repository Citation
Goswami, A.,
Kaur, N.,
Kaur, M.,
Singh, K.,
Sohal, H. S.,
Han, H.,
Bhowmik, P. K.
(2024).
Facile One-Pot Synthesis and Anti-Microbial Activity of Novel 1,4-Dihydropyridine Derivatives in Aqueous Micellar Solution under Microwave Irradiation.
Molecules, 29(5),
1-12.
http://dx.doi.org/10.3390/molecules29051115