Sex Moderates the Impact of Diagnosis and Amyloid PET Positivity on Hippocampal Subfield Volume

Authors

Jessica Z. K. Caldwell, Cleveland Clinic Lou Ruvo Center for Brain HealthFollow
Jody-Lynn Berg, Cleveland Clinic Lou Ruvo Center for Brain Health
Guogen Shan, University of Nevada, Las VegasFollow
Jeffrey L. Cummings, Cleveland Clinic Lou Ruvo Center for Brain Health
Sarah J. Banks, Cleveland Clinic Lou Ruvo Center for Brain HealthFollow

Document Type

Article

Publication Date

6-8-2018

Publication Title

Journal of Alzheimer's Disease

Volume

64

Issue

1

First page number:

79

Last page number:

89

Abstract

We examined moderation effects of sex and diagnosis on the effect of positive florbetapir positron emission tomography (PET) amyloid-β (Aβ) scan (A+) on hippocampus subfield volumes in 526 normal control (NC) and early mild cognitive impairment (eMCI) participants from the Alzheimer’s Disease Neuroimaging Initiative (ADNI2; ADNI-GO). Regression moderation models showed that women— but not men— with NC designation did not show reduced subiculum volumes despite A+. At the eMCI stage, A+ was detrimental across sexes. Findings were significant while accounting for the effects of age, cognition at screening, education, and APOE4 carrier status. These findings suggest that women with A+ have early neural resistance to Alzheimer’s disease-related amyloid burden.

Keywords

Alzheimer's disease; Amyloidmagnetic resonance imaging; Memory; Mild cognitive impairment; Positron emission tomography

Disciplines

Analytical, Diagnostic and Therapeutic Techniques and Equipment | Community Health and Preventive Medicine

Language

English

Repository Citation

Caldwell, J. Z., Berg, J., Shan, G., Cummings, J. L., Banks, S. J. (2018). Sex Moderates the Impact of Diagnosis and Amyloid PET Positivity on Hippocampal Subfield Volume. Journal of Alzheimer's Disease, 64(1), 79-89.
http://dx.doi.org/10.3233/JAD-180028