Sex Moderates the Impact of Diagnosis and Amyloid PET Positivity on Hippocampal Subfield Volume

Document Type

Article

Publication Date

6-8-2018

Publication Title

Journal of Alzheimer's Disease

Volume

64

Issue

1

First page number:

79

Last page number:

89

Abstract

We examined moderation effects of sex and diagnosis on the effect of positive florbetapir positron emission tomography (PET) amyloid-β (Aβ) scan (A+) on hippocampus subfield volumes in 526 normal control (NC) and early mild cognitive impairment (eMCI) participants from the Alzheimer’s Disease Neuroimaging Initiative (ADNI2; ADNI-GO). Regression moderation models showed that women— but not men— with NC designation did not show reduced subiculum volumes despite A+. At the eMCI stage, A+ was detrimental across sexes. Findings were significant while accounting for the effects of age, cognition at screening, education, and APOE4 carrier status. These findings suggest that women with A+ have early neural resistance to Alzheimer’s disease-related amyloid burden.

Keywords

Alzheimer's disease; Amyloidmagnetic resonance imaging; Memory; Mild cognitive impairment; Positron emission tomography

Disciplines

Analytical, Diagnostic and Therapeutic Techniques and Equipment | Community Health and Preventive Medicine

Language

English

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