Concurrent sound segregation impairments in schizophrenia: The contribution of auditory-specific and general cognitive factors

Authors

Erin M Ramage, University of Nevada, Las Vegas
N Klimas, University of Nevada, Las Vegas
S J. Vogel, University of Nevada, Las VegasFollow
M Vertinski, University of Nevada, Las VegasFollow
B D. Yerkes, University of Nevada, Las VegasFollow
A Flores, University of Nevada, Las VegasFollow
G P. Sutton, University of Nevada, Las VegasFollow
E N. Ringdahl, University of Nevada, Las VegasFollow
Daniel Allen, University of Nevada, Las VegasFollow
J S. Snyder, University of Nevada, Las VegasFollow

Document Type

Article

Publication Date

1-1-2016

Publication Title

Schizophrenia Research

Volume

170

Issue

1

First page number:

95

Last page number:

101

Abstract

The present study sought to test whether perceptual segregation of concurrently played sounds is impaired in schizophrenia (SZ), whether impairment in sound segregation predicts difficulties with a real-world speech-in-noise task, and whether auditory-specific or general cognitive processing accounts for sound segregation problems. Participants with SZ and healthy controls (HCs) performed a mistuned harmonic segregation task during recording of event-related potentials (ERPs). Participants also performed a brief speech-in-noise task. Participants with SZ showed deficits in the mistuned harmonic task and the speech-in-noise task, compared to HCs. No deficit in SZ was found in the ERP component related to mistuned harmonic segregation at around 150 ms (the object-related negativity or ORN), but instead showed a deficit in processing at around 400 ms (the P4 response). However, regression analyses showed that indexes of education level and general cognitive function were the best predictors of sound segregation difficulties, suggesting non-auditory specific causes of concurrent sound segregation problems in SZ. © 2015 Elsevier B.V.

Keywords

Auditory scene analysis; Event-related brain potentials; Hallucinations; Mistuned harmonic segregation; Speech-in-noise

Language

English

Repository Citation

Ramage, E., Klimas, N., Vogel, S. J., Vertinski, M., Yerkes, B. D., Flores, A., Sutton, G. P., Ringdahl, E. N., Allen, D., Snyder, J. S. (2016). Concurrent sound segregation impairments in schizophrenia: The contribution of auditory-specific and general cognitive factors. Schizophrenia Research, 170(1), 95-101.
http://dx.doi.org/10.1016/j.schres.2015.11.023