Document Type

Article

Publication Date

1-1-2018

Publication Title

Alzheimer’s & Dementia: Translational Research & Clinical Interventions

Volume

4

First page number:

575

Last page number:

590

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is characterized by cognitive decline and the presence of two core pathologies, amyloid β plaques and neurofibrillary tangles. Over the last decade, the presence of a sustained immune response in the brain has emerged as a third core pathology in AD. The sustained activation of the brain's resident macrophages (microglia) and other immune cells has been demonstrated to exacerbate both amyloid and tau pathology and may serve as a link in the pathogenesis of the disorder. In the following review, we provide an overview of inflammation in AD and a detailed coverage of a number of microglia-related signaling mechanisms that have been implicated in AD. Additional information on microglia signaling and a number of cytokines in AD are also reviewed. We also review the potential connection of risk factors for AD and how they may be related to inflammatory mechanisms.

Keywords

Alzheimer's disease; Cytokines; Inflammation; Microglia; Microglia receptors

Disciplines

Psychological Phenomena and Processes

File Format

PDF

File Size

676 Kb

Language

English

Creative Commons License

Creative Commons Attribution-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-No Derivative Works 4.0 License.

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