Award Date

1-1-2001

Degree Type

Thesis

Degree Name

Master of Science (MS)

Department

Mechanical Engineering

First Committee Member

Bingmei Fu

Number of Pages

95

Abstract

Vascular endothelium is the principal barrier to, and regulator of, material exchange between circulating blood and the body tissues. Based on previous research in this field, two new theoretical models have been developed in this thesis. One is to investigate structural mechanisms in the regulation of microvessel permeability by cAMP. The other is to examine the charge effects of surface glycocalyx on microvessel permeability; To investigate the microstructural mechanisms of decreasing microvascular permeability induced by the enhancement of intraendothelial adenosine 3 ',5'-cyclic monophosphate (CAMP) levels, we extended the previous analytical model developed by Fu et al. (1994) for the interendothelial cleft to include multiple junction strands in the cleft and an interface between the surface glycocalyx layer and the cleft entrance; Previous experimental studies revealed that the endothelial surface glycocalyx might carry negative charges. To investigate this charge effect on microvessel permeability, we extended the three-dimensional (3-D) junction-orifice-fiber matrix model developed by Fu et al. (1994) for the interendothelial cleft to include a negatively charged glycocalyx layer at the entrance of the interendothelial cleft. (Abstract shortened by UMI.).

Keywords

Cleft; Interendothelial; Mathematical; Models

Controlled Subject

Mechanical engineering; Physiology

File Format

pdf

File Size

2406.4 KB

Degree Grantor

University of Nevada, Las Vegas

Language

English

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