Award Date
1-1-2001
Degree Type
Thesis
Degree Name
Master of Science (MS)
Department
Mechanical Engineering
First Committee Member
Bingmei Fu
Number of Pages
95
Abstract
Vascular endothelium is the principal barrier to, and regulator of, material exchange between circulating blood and the body tissues. Based on previous research in this field, two new theoretical models have been developed in this thesis. One is to investigate structural mechanisms in the regulation of microvessel permeability by cAMP. The other is to examine the charge effects of surface glycocalyx on microvessel permeability; To investigate the microstructural mechanisms of decreasing microvascular permeability induced by the enhancement of intraendothelial adenosine 3 ',5'-cyclic monophosphate (CAMP) levels, we extended the previous analytical model developed by Fu et al. (1994) for the interendothelial cleft to include multiple junction strands in the cleft and an interface between the surface glycocalyx layer and the cleft entrance; Previous experimental studies revealed that the endothelial surface glycocalyx might carry negative charges. To investigate this charge effect on microvessel permeability, we extended the three-dimensional (3-D) junction-orifice-fiber matrix model developed by Fu et al. (1994) for the interendothelial cleft to include a negatively charged glycocalyx layer at the entrance of the interendothelial cleft. (Abstract shortened by UMI.).
Keywords
Cleft; Interendothelial; Mathematical; Models
Controlled Subject
Mechanical engineering; Physiology
File Format
File Size
2406.4 KB
Degree Grantor
University of Nevada, Las Vegas
Language
English
Permissions
If you are the rightful copyright holder of this dissertation or thesis and wish to have the full text removed from Digital Scholarship@UNLV, please submit a request to digitalscholarship@unlv.edu and include clear identification of the work, preferably with URL.
Repository Citation
Chen, Bin, "Mathematical models for interendothelial cleft" (2001). UNLV Retrospective Theses & Dissertations. 1316.
http://dx.doi.org/10.25669/3ski-vrd1
Rights
IN COPYRIGHT. For more information about this rights statement, please visit http://rightsstatements.org/vocab/InC/1.0/
