Award Date

1-1-2004

Degree Type

Thesis

Degree Name

Master of Science (MS)

Department

Environmental Science

First Committee Member

Shawn L. Gerstenberger

Number of Pages

55

Abstract

Pregnant Long Evans rats were exposed to ammonioum perchlorate in their drinking water at doses of 0.8 mg/kg-day and 8.7 mg/kg-day (or at concentrations of 5.0 mg/L perchlorate and 50.0 mg/L perchlorate) from GD 7-GD 21. The offspring were observed for developmental landmarks and tested in a battery of behavior trials. Dams exposed at the 5.0 mg/kg-day perchlorate exhibited delayed or deficient responses in the number of pups per dam, pinna unfolding, negative geotaxis, startle response IP on PND 61, figure 8 maze on PND 21, and a more reactive tactile startle response on PND 21. Pups exposed at the higher concentrations showed delayed pinna unfolding, delayed negative geotaxis, and less reactive tactile startle response on PNDs 21 and 61, and a more reactive startle response IP on PND 21. The low dose-dependent effects observed in this experiment indicate that a U-shaped linear dose-response curve may be supported and behavioral responses appear to be compensatory and temporal after exposure to perchlorate during gestation.

Keywords

Behavior; Development; Effects; Exposure; Gestational; Perchlorate; Rats

Controlled Subject

Toxicology; Physiology

File Format

pdf

File Size

1566.72 KB

Degree Grantor

University of Nevada, Las Vegas

Language

English

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