Award Date

1-1-2007

Degree Type

Thesis

Degree Name

Master of Science (MS)

Department

Chemistry

First Committee Member

Vernon Hodge

Number of Pages

65

Abstract

Cisplatin is used clinically to treat various types of cancer. While effective in treating a variety of cancers it exhibits a wide range of side effects. Synthesis of novel cisplatin analogs, which exhibit increased cytotoxicity at lower doses, may alleviate some of the side effects; These analogs utilize 4,4'-bis(alkyl)-2,2'-bipyridine, a diimine, in place of the ammonia ligands present in cisplatin and the addition of substituents to the 4,4'-position as well as coordination to PtCl2 to yield a series of (4,4'-bis[alkyl]-2,2'-bipyridine) PtCl2 compounds. Modifications at the 4,4'-position occur by generating a benzylic dianion by way of lithium diisopropyl amide (LDA) and then substituting with the desired alkyl halide in a SN2 reaction. The different substitutions made in the 4,4' position are as follows: ethyl, propyl, n-butyl, methoxy and 3-methoxy-n-propyl. All of the coordination reactions have been done by ligand exchange where by PtCl2 exchanges from 1,5-cyclooctadiene (COD) to the bipyridine ligand.

Keywords

Analogues; Bipyridine; Cisplatin; Containing; Derivatives

Controlled Subject

Organic chemistry; Pharmacology; Biochemistry

File Format

pdf

File Size

1239.04 KB

Degree Grantor

University of Nevada, Las Vegas

Language

English

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