Award Date
1-1-2007
Degree Type
Thesis
Degree Name
Master of Science (MS)
Department
Chemistry
First Committee Member
Stephen W. Carper
Number of Pages
111
Abstract
The antitumor agent that is most prescribed for the treatment of cancer is cis-diamminedichloroplatinum (II) (cisplatin), but its application is limited due to toxic side effects; especially nephrotoxicity. Due to these limitations, numerous analogs have been developed. The cytotoxicity of five novel cisplatin analogs, dichloro(4,4'-diethyl-2,2'-bipyridine)platinum, dichloro(4,4'-dipropyl-2,2'-bipyridine)platinum, dichloro(4,4'-di-t-butyl-2,2'-bipyridine)platinum, dichloro(4,4'-dimethoxy-2,2'-bipyridine)platinum and dichloro[4,4'-bis(3-methoxypropyl)-2,2'-bipyridine]platinum, in lung (A549), prostate (DU-145) and five breast (MCF-7, MDA-MB-435, MDA-MB-231, DC4 and DB46) cancer cell lines were investigated. Clonogenic survivals demonstrated that these novel analogs were 47 to 242 times more lethal than cisplatin and killed cells predominately by apoptosis. The analogs did not typically cause a block in the cell cycle. Results from clonogenic survivals and calculation of the combination index (CI) revealed that several analogs had slightly synergistic interactions with ionizing radiation to kill prostate and breast cancer cell lines. Results indicate that these novel analogs may be potential antitumor agents in clinical treatment.
Keywords
Analogs; Breast; Cancer; Cells; Cisplatin; Cytotoxicity; Lung; Novel; Prostate
Controlled Subject
Biochemistry; Pharmacology
File Format
File Size
2836.48 KB
Degree Grantor
University of Nevada, Las Vegas
Language
English
Permissions
If you are the rightful copyright holder of this dissertation or thesis and wish to have the full text removed from Digital Scholarship@UNLV, please submit a request to digitalscholarship@unlv.edu and include clear identification of the work, preferably with URL.
Repository Citation
Vo, Van, "Cytotoxicity of novel cisplatin analogs in lung, prostate and breast cancer cells" (2007). UNLV Retrospective Theses & Dissertations. 2196.
http://dx.doi.org/10.25669/fys6-5g60
Rights
IN COPYRIGHT. For more information about this rights statement, please visit http://rightsstatements.org/vocab/InC/1.0/
