Award Date

1-1-1993

Degree Type

Thesis

Degree Name

Master of Science (MS)

Department

Chemistry

First Committee Member

Vernon Hodge

Number of Pages

66

Abstract

A method of tuning and calibration for a thermospray ion source on a benchtop quadrupole mass spectrometer using trifluoroacetic acid, pentafluoropropionic acid, heptafluorobutyric acid, polytetrahydrofuran-250, and polytetrahydrofuran-650 was proposed and evaluated. A 0.5% solution of the aliphatic acids showed good mass range coverage (163-641) in the negative mode, and no substantial memory effects. This mixture was evaluated over 45 days for fluctuations in the ion intensities and ratios. It remained stable within the expected thermospray reproducibility range, although the volatility of the trifluoroacetic acid made daily preparation of standard mixtures necessary. A similar solution of the polytetrahydrofurans was evaluated in both the positive and the negative ionization mode. While several high mass ions were identified in the resulting spectra, these compounds lacked the reproducibility and predictability required, and were dropped from further evaluation.

Keywords

Acids; Agents; Aliphatic; Calibration; Calibrationagents; Evaluation; Hplc; Polytetrahydrofurans; Selected; Thermospray

Controlled Subject

Chemistry, Analytic

File Format

pdf

File Size

1914.88 KB

Degree Grantor

University of Nevada, Las Vegas

Language

English

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