Award Date

May 2017

Degree Type

Thesis

Degree Name

Master of Science (MS)

Department

Kinesiology and Nutrition Sciences

First Committee Member

Jessica Knurick

Second Committee Member

John Young

Third Committee Member

Laura Kruskall

Fourth Committee Member

Catherine Turner

Number of Pages

90

Abstract

Background: Hunger hormone levels are typically dysregulated in obese and diabetic

populations, however; postprandial exercise has been shown to influence hunger hormone levels. Purpose: To determine if hunger hormones including acylated ghrelin and GLP-1 levels are altered in response to an acute bout (15 minutes) of walking in individuals at risk for type 2 diabetes mellitus (T2DM).

Methods: Ten subjects at risk for prediabetes (fasting blood glucose 100–125mg/dL) participated in this randomized crossover design trial. Subjects arrived at the laboratory following an overnight fast and underwent one of two conditions: 1) Test meal with no walking (CON) or 2) Test meal followed by a 15-minute treadmill walk at preferred walking speed (WALK). Blood samples were taken over two hours and assayed for acylated ghrelin and active GLP-1. A repeated measures ANOVA was used to compare mean differences for all outcome variables.

Results: There were no statistical differences in acylated ghrelin (F = 1.535, p = 0.247) or GLP-1 (F = 0.003, p = 0.955) concentrations between CON and WALK conditions at any time period. There was a main effect of time for ghrelin (F = 41.339; p < 0.001). Post hoc analysis indicated a significant difference between baseline and 60 minutes (p < 0.001) and between baseline and 120 minutes (p < 0.001) for acylated ghrelin concentrations. No difference was found between 60 minutes and 120 minutes (p = 0.834). There was a main effect of time for GLP-1 (F = 17.968; p < 0.001). Post hoc analysis indicated a significant difference between baseline and 60 minutes (p = 0.001) and between baseline and 120 minutes (p = 0.002) for GLP-1 concentrations. No difference was found between 60 minutes and 120 minutes (p = 0.665). There was no significant difference in the AUC for acylated ghrelin between the CON and WALK conditions (t = -1.257;

p = 0.240). There was no significant difference in the AUC for GLP-1 between the CON and WALK conditions (t = -0.107; p = 0.918). Correlations between perceived hunger and biological hunger were weak and nonsignificant (p > 0.05).

Conclusion: A 15-minute walk performed shortly after a meal does not have a significant impact on hunger hormones including acylated ghrelin and active GLP-1 concentrations in individuals at risk for T2DM.

Keywords

Diabetes; Hunger Hormones; Obesity; Postprandial; Walking

Disciplines

Kinesiology | Medicine and Health Sciences | Nutrition

File Format

pdf

Degree Grantor

University of Nevada, Las Vegas

Language

English

Rights

IN COPYRIGHT. For more information about this rights statement, please visit http://rightsstatements.org/vocab/InC/1.0/

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