Award Date
5-17-2019
Degree Type
Dissertation
Degree Name
Doctor of Physical Therapy (DPT)
Department
Physical Therapy
Advisor 1
Merrill Landers
First Committee Member
Merrill Landers
Second Committee Member
Daniel Young
Number of Pages
19
Abstract
Brain-derived neurotrophic factor (BDNF) levels play an important role in neuroplasticity in normal and neurologically compromised individuals. Studies suggest that BDNF levels increase in response to physical activity and are also affected by genotype. In individuals with Parkinson’s Disease (PD), it is not known if physical activity habits and BDNF genotype modulate this neuroprotective response. The purpose of this study was to determine if BDNF genotype interacts with lifetime self-reported physical activity levels to affect age of disease onset and severity of PD symptoms, specifically gait, balance, and motor dysfunction
Keywords
Parkinson’s Disease; BDNF
Disciplines
Medicine and Health Sciences | Physical Therapy | Rehabilitation and Therapy
File Format
File Size
431 KB
Degree Grantor
University of Nevada, Las Vegas
Language
English
Repository Citation
Johnson, Samantha and Ormsby, Tyler, "The Moderation Effect of BDNF Genotype and Self-Reported Lifetime Physical Activity Habits on Postural Instability in Parkinson’s Disease" (2019). UNLV Theses, Dissertations, Professional Papers, and Capstones. 3762.
http://dx.doi.org/10.34917/18145047
Rights
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