Award Date
August 2023
Degree Type
Dissertation
Degree Name
Doctor of Philosophy (PhD)
Department
Interdisciplinary Programs
First Committee Member
Graham McGinnis
Second Committee Member
James Navalta
Third Committee Member
John Mercer
Fourth Committee Member
Dustin Hines
Number of Pages
154
Abstract
Circadian rhythms lie within every tissue and cell and regulate cellular and tissue processes and functions based upon the time of day. Disrupting the circadian clock results in impaired tissue and organ activity and higher risk of cardiometabolic diseases. A common form of circadian rhythm disruption is social jetlag (SJL), which represents the misalignment of sleep and wake times on free days and work days (i.e. weekend). The time of day of exercise affects the adaptations that are derived from exercise. Within the heart muscle, disparate levels of exercise-induced hypertrophy, circadian clock gene expression, and mitochondrial content were all dependent upon when exercise was performed, all without disrupting the light:dark cycle. Exercise is a potent therapeutic that improves obesity, glucose tolerance, and cardiometabolic health. When circadian rhythms were disrupted with SJL exercise caused faster resynchronization back to weekday activity. However, SJL also caused fasting blood glucose and overall glucose tolerance were impaired in both sedentary and exercising mice. While exercise prevented SJL-induced weight gain, SJL hampered exercise performance and inhibited exercise-induced mitochondrial adaptations in both the heart and skeletal muscle. The findings of this dissertation suggest that adaptation to exercise is affected by the status of the circadian rhythm, and that disrupting light:dark cycles or normal activity rhythms results in impaired adaptations in the heart and skeletal muscle.
Keywords
Exercise physiology; sport science
Disciplines
Kinesiology
File Format
File Size
4650 KB
Degree Grantor
University of Nevada, Las Vegas
Language
English
Repository Citation
Dial, Michael Bevan, "Effects of Circadian Rhythm Disruption and Social Jetlag on the Cardiometabolic Adaptations to Exercise" (2023). UNLV Theses, Dissertations, Professional Papers, and Capstones. 4824.
http://dx.doi.org/10.34917/36948174
Rights
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