Base-Controlled Fe(Pc)-Catalyzed Aerobic Oxidation of Thiols for the Synthesis of S-S and S-P(O) Bonds
Document Type
Article
Publication Date
5-17-2018
Publication Title
Organic and Biomolecular Chemistry
Volume
16
Issue
23
First page number:
4236
Last page number:
4242
Abstract
Fe(Pc)-Catalyzed aerobic oxidation of thiols for the synthesis of disulfides has been developed under mild reaction conditions. In addition, an aerobic oxidative cross-dehydrogenative coupling (CDC) reaction of thiols with P(O)–H compounds (H-phosphonates and H-phosphine oxide) for the formation of S–P(O) bonds has been demonstrated under the Fe(Pc) catalysis system with a base additive. Control experiments revealed that the use of a base (DIPA) in this system controls the synthetic pathways in which thiophosphates are formed.
Disciplines
Organic Chemistry
Language
English
Repository Citation
Huang, H.,
Ash, J.,
Kang, J. Y.
(2018).
Base-Controlled Fe(Pc)-Catalyzed Aerobic Oxidation of Thiols for the Synthesis of S-S and S-P(O) Bonds.
Organic and Biomolecular Chemistry, 16(23),
4236-4242.
http://dx.doi.org/10.1039/C8OB00908B