Tf2O-Promoted Activating Strategy of Phosphate Analogues: Synthesis of Mixed Phosphates and Phosphinate
Document Type
Article
Publication Date
8-8-2018
Publication Title
Organic Letters
Volume
20
Issue
16
First page number:
4938
Last page number:
4941
Abstract
A metal-, toxic chloride reagent-free activating strategy of various phosphates has been developed. This method enables the facile synthesis of functional phosphates such as alkyl phosphates, aza phosphates, thiophosphate, and mixed diaryl phosphates. A transient phosphorylpyridin-1-ium species in situ generated from phosphates with Tf2O/pyridine readily undergoes a substitution reaction with diverse nucleophiles to form versatile phosphate compounds.
Disciplines
Chemistry
Language
English
Repository Citation
Huang, H.,
Ash, J.,
Kang, J.
(2018).
Tf2O-Promoted Activating Strategy of Phosphate Analogues: Synthesis of Mixed Phosphates and Phosphinate.
Organic Letters, 20(16),
4938-4941.
http://dx.doi.org/10.1021/acs.orglett.8b02073