Spectra Undergraduate Research Journal
Submission Title
The Utilization of CRISPR/Cas9 in Monogenic Disorders Authors
Category
Health & Natural Sciences & Engineering > Natural Sciences > Kinesiology
Received
April 20, 2022
Accepted
August 19, 2022
Published
August 31, 2022
Copyright
Articles in Spectra are freely available under a Creative Commons Attribution License (CC BY 4.0) which allows others to re-use the work without permission as long as the work is properly cited.
Data Availability Statement
The authors of this article confirm that all data underlying the findings are fully available without restrictions.
Conflicts of Interest
The authors declare that they have no conflict of interest.
Ethical Considerations
Given that this project did not involve human or animal subjects, no IRB or IACUC approval was needed. All research was derived from publicly shared sources.
Abstract
This paper is a literature review of various scientific research papers, exploring the recent scientific advancement in the field of genetic engineering. The research presented is a foundational tool, building awareness on the implications of CRISPR/ Cas9 technology. CRISPR/ Cas9 was first discovered through the study of bacterial immune systems, fighting against viral infections. Manipulation of the Cas9 protein would eventually lead to target specific, gene-altering medicines for human organisms. CRISPR/ Cas 9 technology has begun to show promise as an effective treatment for certain monogenic disorders. Despite this, time is required before its efficacy as a proven genetic treatment plan. Certain drawbacks like chromosomal rearrangements and the formation of cancerous cells, reveal the potential negative consequences of CRISPR/Cas9 treatment. Careful calculations will be required to ensure the safety and specificity of this technology throughout future clinical trials.
Keywords
CRISPR/ Cas 9, gene editing, genetic engineering, DNA mutation, non homologous end joining, homologous directed repair, Intellia, CRISPR therapeutics, monogenic disorders
Submission Type
Primary review article
Recommended Citation
Mellor, S. M. (2022). The utilization of CRISPR/Cas9 in monogenic disorders. Spectra Undergraduate Research Journal, 2(2), 30-34.https://doi.org/10.9741/2766-7227.1018
COinS
